Verification of the Necessity of the Tolyl Group of PF-543 for Sphingosine Kinase 1 Inhibitory Activity

Verification of the Necessity of the Tolyl Group of PF-543 for Sphingosine Kinase 1 Inhibitory Activity

PF-543, the most potent sphingosine kinase (SK) inhibitor, does not demonstrate effective anticancer activity in some cancer cells, unlike other known SK1 inhibitors. PF-543 has a non-lipid structure with a unique toluene backbone; however, the importance of this structure remains unclear. Therefore...

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Bibliographic Details
Main Authors: Su Bin Kim, Taeho Lee, Hong Seop Moon, Sung Hwan Ki, Yoon Sin Oh, Joo-Youn Lee, Sang-Bum Kim, Jeong-Eun Park, Yongseok Kwon, Sanghee Kim, Dong Jae Baek, Eun-Young Park
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Molecules
Subjects:
sphingosine kinase
PF-543
BODIPY
anticancer
inhibitor
derivative
Online Access:https://www.mdpi.com/1420-3049/25/11/2484

Internet

https://www.mdpi.com/1420-3049/25/11/2484

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