Dietary ketosis improves circadian dysfunction as well as motor symptoms in the BACHD mouse model of Huntington’s disease

Dietary ketosis improves circadian dysfunction as well as motor symptoms in the BACHD mouse model of Huntington’s disease

Disturbances in sleep/wake cycles are common among patients with neurodegenerative diseases including Huntington’s disease (HD) and represent an appealing target for chrono-nutrition-based interventions. In the present work, we sought to determine whether a low-carbohydrate, high-fat diet would amel...

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Bibliographic Details
Main Authors: Daniel S. Whittaker, T. Katherine Tamai, Raj S. Bains, Sophia Anne Marie Villanueva, Shu Hon Christopher Luk, Derek Dell’Angelica, Gene D. Block, Cristina A. Ghiani, Christopher S. Colwell
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Nutrition
Subjects:
BACHD mice
circadian rhythms
ketogenic diet (KD)
sleep
motor performance
activity rhythm
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2022.1034743/full

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