Pan-cancer surveys indicate cell cycle-related roles of primate-specific genes in tumors and embryonic cerebrum

Pan-cancer surveys indicate cell cycle-related roles of primate-specific genes in tumors and embryonic cerebrum

Abstract Background Despite having been extensively studied, it remains largely unclear why humans bear a particularly high risk of cancer. The antagonistic pleiotropy hypothesis predicts that primate-specific genes (PSGs) tend to promote tumorigenesis, while the molecular atavism hypothesis predict...

Full description

Bibliographic Details
Main Authors: Chenyu Ma, Chunyan Li, Huijing Ma, Daqi Yu, Yufei Zhang, Dan Zhang, Tianhan Su, Jianmin Wu, Xiaoyue Wang, Li Zhang, Chun-Long Chen, Yong E. Zhang
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Genome Biology
Subjects:
Molecular atavism
Antagonistic pleiotropy
Primate-specific genes
Cancer evolution
Brain evolution
Cell cycle
Online Access:https://doi.org/10.1186/s13059-022-02821-9

Internet

https://doi.org/10.1186/s13059-022-02821-9

Similar Items