Simultaneous binding of the anti-cancer IgM monoclonal antibody PAT-SM6 to low density lipoproteins and GRP78.

Simultaneous binding of the anti-cancer IgM monoclonal antibody PAT-SM6 to low density lipoproteins and GRP78.

The tumour-derived monoclonal IgM antibody PAT-SM6 specifically kills malignant cells by an apoptotic mechanism linked to the excessive uptake of plasma lipids. The mechanism is postulated to occur via the multi-point attachment of PAT-SM6 to the unfolded protein response regulator GRP78, located on...

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Bibliographic Details
Main Authors: Zachary Rosenes, Yee-Foong Mok, Shuo Yang, Michael D W Griffin, Terrence D Mulhern, Danny M Hatters, Frank Hensel, Geoffrey J Howlett
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3631193?pdf=render

Internet

http://europepmc.org/articles/PMC3631193?pdf=render

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