Methylglyoxal Impairs the Pro-Angiogenic Ability of Mouse Adipose-Derived Stem Cells (mADSCs) via a Senescence-Associated Mechanism

Methylglyoxal Impairs the Pro-Angiogenic Ability of Mouse Adipose-Derived Stem Cells (mADSCs) via a Senescence-Associated Mechanism

Adipose-derived stem cells (ADSCs) play a crucial role in angiogenesis and repair of damaged tissues. However, in pathological conditions including diabetes, ADSC function is compromised. This work aims at evaluating the effect of Methylglyoxal (MGO), a product of chronic hyperglycemia, on mouse ADS...

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Bibliographic Details
Main Authors: Alessia Leone, Antonella Nicolò, Immacolata Prevenzano, Federica Zatterale, Michele Longo, Antonella Desiderio, Rosa Spinelli, Michele Campitelli, Domenico Conza, Gregory Alexander Raciti, Francesco Beguinot, Cecilia Nigro, Claudia Miele
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cells
Subjects:
adipose-derived stem cells
advanced glycation end-products
angiogenesis
cell migration
dicarbonyl stress
endothelial cells
Online Access:https://www.mdpi.com/2073-4409/12/13/1741

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https://www.mdpi.com/2073-4409/12/13/1741

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