Modifying oncolytic virotherapy to overcome the barrier of the hypoxic tumor microenvironment. Where do we stand?
Abstract Viruses are completely dependent on host cell machinery for their reproduction. As a result, factors that influence the state of cells, such as signaling pathways and gene expression, could determine the outcome of viral pathogenicity. One of the important factors influencing cells or the o...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-022-02774-w |
| _version_ | 1811211116612681728 |
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| author | Sara Shayan Arash Arashkia Kayhan Azadmanesh |
| author_facet | Sara Shayan Arash Arashkia Kayhan Azadmanesh |
| author_sort | Sara Shayan |
| collection | DOAJ |
| description | Abstract Viruses are completely dependent on host cell machinery for their reproduction. As a result, factors that influence the state of cells, such as signaling pathways and gene expression, could determine the outcome of viral pathogenicity. One of the important factors influencing cells or the outcome of viral infection is the level of oxygen. Recently, oncolytic virotherapy has attracted attention as a promising approach to improving cancer treatment. However, it was shown that tumor cells are mostly less oxygenated compared with their normal counterparts, which might affect the outcome of oncolytic virotherapy. Therefore, knowing how oncolytic viruses could cope with stressful environments, particularly hypoxic environments, might be essential for improving oncolytic virotherapy. |
| first_indexed | 2024-04-12T05:07:15Z |
| format | Article |
| id | doaj.art-ae88ebf644854b5aa393382e0af689eb |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-04-12T05:07:15Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-ae88ebf644854b5aa393382e0af689eb2022-12-22T03:46:51ZengBMCCancer Cell International1475-28672022-11-0122111110.1186/s12935-022-02774-wModifying oncolytic virotherapy to overcome the barrier of the hypoxic tumor microenvironment. Where do we stand?Sara Shayan0Arash Arashkia1Kayhan Azadmanesh2Department of Molecular Virology, Pasteur Institute of IranDepartment of Molecular Virology, Pasteur Institute of IranDepartment of Molecular Virology, Pasteur Institute of IranAbstract Viruses are completely dependent on host cell machinery for their reproduction. As a result, factors that influence the state of cells, such as signaling pathways and gene expression, could determine the outcome of viral pathogenicity. One of the important factors influencing cells or the outcome of viral infection is the level of oxygen. Recently, oncolytic virotherapy has attracted attention as a promising approach to improving cancer treatment. However, it was shown that tumor cells are mostly less oxygenated compared with their normal counterparts, which might affect the outcome of oncolytic virotherapy. Therefore, knowing how oncolytic viruses could cope with stressful environments, particularly hypoxic environments, might be essential for improving oncolytic virotherapy.https://doi.org/10.1186/s12935-022-02774-wOncolytic virusHypoxiaNormoxiaTumor microenvironment |
| spellingShingle | Sara Shayan Arash Arashkia Kayhan Azadmanesh Modifying oncolytic virotherapy to overcome the barrier of the hypoxic tumor microenvironment. Where do we stand? Cancer Cell International Oncolytic virus Hypoxia Normoxia Tumor microenvironment |
| title | Modifying oncolytic virotherapy to overcome the barrier of the hypoxic tumor microenvironment. Where do we stand? |
| title_full | Modifying oncolytic virotherapy to overcome the barrier of the hypoxic tumor microenvironment. Where do we stand? |
| title_fullStr | Modifying oncolytic virotherapy to overcome the barrier of the hypoxic tumor microenvironment. Where do we stand? |
| title_full_unstemmed | Modifying oncolytic virotherapy to overcome the barrier of the hypoxic tumor microenvironment. Where do we stand? |
| title_short | Modifying oncolytic virotherapy to overcome the barrier of the hypoxic tumor microenvironment. Where do we stand? |
| title_sort | modifying oncolytic virotherapy to overcome the barrier of the hypoxic tumor microenvironment where do we stand |
| topic | Oncolytic virus Hypoxia Normoxia Tumor microenvironment |
| url | https://doi.org/10.1186/s12935-022-02774-w |
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