BMX Acts Downstream of PI3K to Promote Colorectal Cancer Cell Survival and Pathway Inhibition Sensitizes to the BH3 Mimetic ABT-737

BMX Acts Downstream of PI3K to Promote Colorectal Cancer Cell Survival and Pathway Inhibition Sensitizes to the BH3 Mimetic ABT-737

Evasion of apoptosis is a hallmark of cancer, and reversing this process by inhibition of survival signaling pathways is a potential therapeutic strategy. Phosphoinositide 3-kinase (PI3K) signaling can promote cell survival and is upregulated in solid tumor types, including colorectal cancer (CRC),...

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Bibliographic Details
Main Authors: Danielle S. Potter, Paul Kelly, Olive Denneny, Veronique Juvin, Len R. Stephens, Caroline Dive, Christopher J. Morrow
Format: Article
Language:English
Published: Elsevier 2014-02-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558614800146

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http://www.sciencedirect.com/science/article/pii/S1476558614800146

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