Metabolomics of small extracellular vesicles derived from isocitrate dehydrogenase 1-mutant HCT116 cells collected by semi-automated size exclusion chromatography

Metabolomics of small extracellular vesicles derived from isocitrate dehydrogenase 1-mutant HCT116 cells collected by semi-automated size exclusion chromatography

Cancer-derived small extracellular vesicles (sEVs) are multifunctional particles with a lipid bilayer structure that are involved in cancer progression, such as malignant proliferation, distant metastasis, and cancer immunity evasion. The separation protocol used to isolate sEVs is an important proc...

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Bibliographic Details
Main Authors: Ryosuke Hayasaka, Sho Tabata, Masako Hasebe, Satsuki Ikeda, Tomoya Hikita, Chitose Oneyama, Jun Yoshitake, Daisuke Onoshima, Kumiko Takahashi, Takahiro Shibata, Koji Uchida, Yoshinobu Baba, Tomoyoshi Soga, Masaru Tomita, Akiyoshi Hirayama
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Molecular Biosciences
Subjects:
small extracellular vesicles
size exclusion chromatography
ultracentrifugation
metabolome analysis
lipidome analysis
2-hydroxyglutaric acid
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.1049402/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.1049402/full

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