In Silico Identification and In Vitro Evaluation of New ABCG2 Transporter Inhibitors as Potential Anticancer Agents

In Silico Identification and In Vitro Evaluation of New ABCG2 Transporter Inhibitors as Potential Anticancer Agents

Different molecular mechanisms contribute to the development of multidrug resistance in cancer, including increased drug efflux, enhanced cellular repair mechanisms and alterations of drug metabolism or drug targets. ABCG2 is a member of the ATP-binding cassette superfamily transporters that promote...

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Bibliographic Details
Main Authors: Simone Di Micco, Veronica Di Sarno, Martina Rossi, Vincenzo Vestuto, Takumi Konno, Sara Novi, Mario Felice Tecce, Valeria Napolitano, Tania Ciaglia, Andrea Vitale, Isabel Maria Gomez-Monterrey, Giuseppe Bifulco, Alessia Bertamino, Carmine Ostacolo, Paolo Blasi, Alessio Fasano, Pietro Campiglia, Simona Musella
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
drug discovery
in silico studies
multidrug resistance
multicellular tumor spheroids
ATP-binding cassette
Online Access:https://www.mdpi.com/1422-0067/24/1/725

Internet

https://www.mdpi.com/1422-0067/24/1/725

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