Phosphorylation-dependent allosteric regulation of Cx43 gap junction inhibitor potency

Phosphorylation-dependent allosteric regulation of Cx43 gap junction inhibitor potency

Physiological and pathological processes such as homeostasis, embryogenesis, development, tumorigenesis, and cell movement depend on the intercellular communication through gap junctions (GJIC). Connexin (Cx)-based GJ channels are formed of two apposing hemichannels in the contiguous cells and provi...

Full description

Bibliographic Details
Main Authors: Rokas Mickus, Vytautas Raškevičius, Ieva Sarapinienė, Valeryia Mikalayeva, Rytis Prekeris, Vytenis Arvydas Skeberdis
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Gap junctions
Connexin 43
Phosphorylation
Inhibitor potency
Ca2+-dependent kinases
Allosteric regulation
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224004347

Internet

http://www.sciencedirect.com/science/article/pii/S0753332224004347

Similar Items