Effective Synthesis of Nucleosides Utilizing O-Acetyl-Glycosyl Chlorides as Glycosyl Donors in the Absence of Catalyst: Mechanism Revision and Application to Silyl-Hilbert-Johnson Reaction

Effective Synthesis of Nucleosides Utilizing O-Acetyl-Glycosyl Chlorides as Glycosyl Donors in the Absence of Catalyst: Mechanism Revision and Application to Silyl-Hilbert-Johnson Reaction

An effective synthesis of nucleosides using glycosyl chlorides as glycosyl donors in the absence of Lewis acid has been developed. Glycosyl chlorides have been shown to be pivotal intermediates in the classical silyl-Hilbert-Johnson reaction. A possible mechanism that differs from the currently acce...

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Bibliographic Details
Main Authors: Chengyuan Liang, Weihui Ju, Shunjun Ding, Han Sun, Gennian Mao
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:Molecules
Subjects:
nucleosides
glycosyl chiorides
N-glycosylation
catalyst free reaction
silyl-Hilbert-Johnson reaction
Online Access:http://www.mdpi.com/1420-3049/22/1/84

Internet

http://www.mdpi.com/1420-3049/22/1/84

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