Fbxw7 suppresses carcinogenesis and stemness in triple-negative breast cancer through CHD4 degradation and Wnt/β-catenin pathway inhibition

Fbxw7 suppresses carcinogenesis and stemness in triple-negative breast cancer through CHD4 degradation and Wnt/β-catenin pathway inhibition

Abstract Background Cancer stem cells (CSCs) are a small population of cells in tumor tissues that can drive tumor initiation and promote tumor progression. A small number of previous studies indirectly mentioned the role of F-box and WD repeat domain-containing 7 (FBXW7) as a tumor suppressor in Tr...

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Dades bibliogràfiques
Autors principals: Guodong Xiao, Weiping Lu, Jing Yuan, Zuyue Liu, Peili Wang, Huijie Fan
Format: Article
Idioma:English
Publicat: BMC 2024-01-01
Col·lecció:Journal of Translational Medicine
Matèries:
Fbxw7
CHD4
Stemness
Wnt/β-catenin
Triple-negative breast cancer
Accés en línia:https://doi.org/10.1186/s12967-024-04897-2

Internet

https://doi.org/10.1186/s12967-024-04897-2

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