Fbxw7 suppresses carcinogenesis and stemness in triple-negative breast cancer through CHD4 degradation and Wnt/β-catenin pathway inhibition

Fbxw7 suppresses carcinogenesis and stemness in triple-negative breast cancer through CHD4 degradation and Wnt/β-catenin pathway inhibition

Abstract Background Cancer stem cells (CSCs) are a small population of cells in tumor tissues that can drive tumor initiation and promote tumor progression. A small number of previous studies indirectly mentioned the role of F-box and WD repeat domain-containing 7 (FBXW7) as a tumor suppressor in Tr...

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Bibliographische Detailangaben
Hauptverfasser:	Guodong Xiao, Weiping Lu, Jing Yuan, Zuyue Liu, Peili Wang, Huijie Fan
Format:	Artikel
Sprache:	English
Veröffentlicht:	BMC 2024-01-01
Schriftenreihe:	Journal of Translational Medicine
Schlagworte:	Fbxw7 CHD4 Stemness Wnt/β-catenin Triple-negative breast cancer
Online Zugang:	https://doi.org/10.1186/s12967-024-04897-2

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