Cbp1 and Cren7 form chromatin-like structures that ensure efficient transcription of long CRISPR arrays

Cbp1 and Cren7 form chromatin-like structures that ensure efficient transcription of long CRISPR arrays

Abstract CRISPR arrays form the physical memory of CRISPR adaptive immune systems by incorporating foreign DNA as spacers that are often AT-rich and derived from viruses. As promoter elements such as the TATA-box are AT-rich, CRISPR arrays are prone to harbouring cryptic promoters. Sulfolobales harb...

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Bibliographic Details
Main Authors: Fabian Blombach, Michal Sýkora, Jo Case, Xu Feng, Diana P. Baquero, Thomas Fouqueau, Duy Khanh Phung, Declan Barker, Mart Krupovic, Qunxin She, Finn Werner
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45728-8

Internet

https://doi.org/10.1038/s41467-024-45728-8

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