A Multifaceted Role of Tryptophan Metabolism and Indoleamine 2,3-Dioxygenase Activity in Aspergillus fumigatus–Host Interactions

A Multifaceted Role of Tryptophan Metabolism and Indoleamine 2,3-Dioxygenase Activity in Aspergillus fumigatus–Host Interactions

Aspergillus fumigatus is the most prevalent filamentous fungal pathogen of humans, causing either severe allergic bronchopulmonary aspergillosis or often fatal invasive pulmonary aspergillosis (IPA) in individuals with hyper- or hypo-immune deficiencies, respectively. Disease is primarily initiated...

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Bibliographic Details
Main Authors: Tsokyi Choera, Teresa Zelante, Luigina Romani, Nancy P. Keller
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
Aspergillus fumigatus
tryptophan metabolism
IDO
kynurenines
toxins
non-ribosomal peptides
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01996/full

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.01996/full

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