Mitotic Phosphorylation of TREX1 C Terminus Disrupts TREX1 Regulation of the Oligosaccharyltransferase Complex

Mitotic Phosphorylation of TREX1 C Terminus Disrupts TREX1 Regulation of the Oligosaccharyltransferase Complex

TREX1 mutations are associated with several autoimmune and inflammatory diseases. The N-terminal DNase domain of TREX1 is important for preventing self-DNA from activating the interferon response. The C terminus of TREX1 is required for ER localization and regulation of oligosacchariyltransferase (O...

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Bibliographic Details
Main Authors: Martin Kucej, Charles S. Fermaintt, Kun Yang, Ricardo A. Irizarry-Caro, Nan Yan
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
TREX1
cell cycle
autoimmune disease
DNase
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717302498

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http://www.sciencedirect.com/science/article/pii/S2211124717302498

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