Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection
Summary: Poly(ADP-ribosyl)ation (PARylation), catalyzed mainly by poly(ADP-ribose) polymerase (PARP)1, is a key posttranslational modification involved in DNA replication and repair. Here, we report that TIMELESS (TIM), an essential scaffold of the replisome, is PARylated, which is linked to its pro...
| Hauptverfasser: | , , , , , |
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| Format: | Artikel |
| Sprache: | English |
| Veröffentlicht: |
Elsevier
2024-03-01
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| Schriftenreihe: | Cell Reports |
| Schlagworte: | |
| Online Zugang: | http://www.sciencedirect.com/science/article/pii/S2211124724001736 |