C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages

C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages

The complement system mediates diverse regulatory immunological functions. C5aR2, an enigmatic receptor for anaphylatoxin C5a, has been shown to modulate PRR-dependent pro-inflammatory cytokine secretion in human macrophages. However, the specific downstream targets and underlying molecular mechanis...

Full description

Bibliographic Details
Main Authors: Oliver Wright, Anna Harris, Van Dien Nguyen, You Zhou, Maxim Durand, Abbie Jayyaratnam, Darren Gormley, Luke A. J. O’Neill, Kathy Triantafilou, Eva Maria Nichols, Lee M. Booty
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cells
Subjects:
complement
C5a
anaphylatoxin receptor
C5aR2
pattern recognition receptor
innate immune sensing
Online Access:https://www.mdpi.com/2073-4409/12/23/2707

Internet

https://www.mdpi.com/2073-4409/12/23/2707

Similar Items