C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages

C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages

The complement system mediates diverse regulatory immunological functions. C5aR2, an enigmatic receptor for anaphylatoxin C5a, has been shown to modulate PRR-dependent pro-inflammatory cytokine secretion in human macrophages. However, the specific downstream targets and underlying molecular mechanis...

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Bibliographic Details
Main Authors:	Oliver Wright, Anna Harris, Van Dien Nguyen, You Zhou, Maxim Durand, Abbie Jayyaratnam, Darren Gormley, Luke A. J. O’Neill, Kathy Triantafilou, Eva Maria Nichols, Lee M. Booty
Format:	Article
Language:	English
Published:	MDPI AG 2023-11-01
Series:	Cells
Subjects:	complement C5a anaphylatoxin receptor C5aR2 pattern recognition receptor innate immune sensing
Online Access:	https://www.mdpi.com/2073-4409/12/23/2707

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