TMF inhibits extracellular matrix degradation by regulating the C/EBPβ/ADAMTS5 signaling pathway in osteoarthritis

TMF inhibits extracellular matrix degradation by regulating the C/EBPβ/ADAMTS5 signaling pathway in osteoarthritis

Osteoarthritis (OA) is a chronic joint disease, characterized by degenerative destruction of articular cartilage. Chondrocytes, the unique cell type in cartilage, mediate the metabolism of extracellular matrix (ECM), which is mainly constituted by aggrecan and type II collagen. A disintegrin and met...

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Bibliographic Details
Main Authors: Zeyu Wang, Weimei Shi, Longhuo Wu, Yaosheng Xiao, Miaofei Wang, Sainan Zhang, Zhixi Chen, Guoqiang Yin, Xunlu Xie, Shengrong Bi, Shiwei Liu, Weihao Kong, Jianguo Zhou
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Osteoarthritis
Extracellular matrix degradation
TMF
C/EBPβ
ADAMTS5
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224003858

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http://www.sciencedirect.com/science/article/pii/S0753332224003858

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