The metabolic fate of oxaliplatin in the biological milieu investigated during in vivo lung perfusion using a unique miniaturized sampling approach based on solid-phase microextraction coupled with liquid chromatography-mass spectrometry

The metabolic fate of oxaliplatin in the biological milieu investigated during in vivo lung perfusion using a unique miniaturized sampling approach based on solid-phase microextraction coupled with liquid chromatography-mass spectrometry

Adjuvant chemotherapy after pulmonary metastasectomy for colorectal cancer may reduce recurrence and improve survival rates; however, the benefits of this treatment are limited by the significant side effects that accompany it. The development of a novel in vivo lung perfusion (IVLP) platform would...

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Bibliographic Details
Main Authors: Mariola Olkowicz, Hernando Rosales-Solano, Khaled Ramadan, Aizhou Wang, Marcelo Cypel, Janusz Pawliszyn
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
colorectal cancer
pulmonary metastases
adjuvant chemotherapy
in vivo lung perfusion
oxaliplatin
solid phase microextraction
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.928152/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.928152/full

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