Vincristine Promotes Transdifferentiation of Fibroblasts Into Myofibroblasts via P38 and ERK Signal Pathways

Vincristine Promotes Transdifferentiation of Fibroblasts Into Myofibroblasts via P38 and ERK Signal Pathways

Background: Vincristine (VCR) is used in the clinic as an anti-tumor drug. VCR can cause pulmonary fibrosis (PF), leading to respiratory failure. The transformation of fibroblasts into myofibroblasts may play a key role in PF. The present study attempted to reveal the molecular mechanism of VCR-indu...

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Bibliographic Details
Main Authors: Hui Xu, Jingwen Yang, Mengyun Tu, Jie Weng, Mengying Xie, Zhiliang Zhou, Peisen Zhou, Liang Wang, Chan Chen, Zhiyi Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
vincristine
pulmonary fibrosis
fibroblast
myofibroblast
MAPK
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.901000/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.901000/full

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