RGS9‐2 rescues dopamine D2 receptor levels and signaling in DYT1 dystonia mouse models

RGS9‐2 rescues dopamine D2 receptor levels and signaling in DYT1 dystonia mouse models

Abstract Dopamine D2 receptor signaling is central for striatal function and movement, while abnormal activity is associated with neurological disorders including the severe early‐onset DYT1 dystonia. Nevertheless, the mechanisms that regulate D2 receptor signaling in health and disease remain poorl...

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Bibliographic Details
Main Authors: Paola Bonsi, Giulia Ponterio, Valentina Vanni, Annalisa Tassone, Giuseppe Sciamanna, Sara Migliarini, Giuseppina Martella, Maria Meringolo, Benjamin Dehay, Evelyne Doudnikoff, Venetia Zachariou, Rose E Goodchild, Nicola B Mercuri, Marcello D'Amelio, Massimo Pasqualetti, Erwan Bezard, Antonio Pisani
Format: Article
Language:English
Published: Springer Nature 2018-12-01
Series:EMBO Molecular Medicine
Subjects:
beta‐arrestin
lysosomal degradation
striatum
Online Access:https://doi.org/10.15252/emmm.201809283

Internet

https://doi.org/10.15252/emmm.201809283

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