Research progress of targeted therapy regulating Th17/Treg balance in bone immune diseases
Rheumatoid arthritis (RA) and postmenopausal osteoporosis (PMOP) are common bone-immune diseases. The imbalance between helper (Th17) and regulatory T cells (Tregs) produced during differentiation of CD4+ T cells plays a key regulatory role in bone remodelling disorders in RA and PMOP. However, the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1333993/full |
| _version_ | 1827369145821298688 |
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| author | Xiaxia Wang Bai Sun Yujie Wang Peng Gao Jiayi Song Weirong Chang Zhipan Xiao Yongbin Xi Zhonghong Li Fangyu An Chunlu Yan |
| author_facet | Xiaxia Wang Bai Sun Yujie Wang Peng Gao Jiayi Song Weirong Chang Zhipan Xiao Yongbin Xi Zhonghong Li Fangyu An Chunlu Yan |
| author_sort | Xiaxia Wang |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) and postmenopausal osteoporosis (PMOP) are common bone-immune diseases. The imbalance between helper (Th17) and regulatory T cells (Tregs) produced during differentiation of CD4+ T cells plays a key regulatory role in bone remodelling disorders in RA and PMOP. However, the specific regulatory mechanism of this imbalance in bone remodelling in RA and PMOP has not been clarified. Identifying the regulatory mechanism underlying the Th17/Treg imbalance in RA and PMOP during bone remodelling represents a key factor in the research and development of new drugs for bone immune diseases. In this review, the potential roles of Th17, Treg, and Th17/Treg imbalance in regulating bone remodelling in RA and PMOP have been summarised, and the potential mechanisms by which probiotics, traditional Chinese medicine compounds, and monomers maintain bone remodelling by regulating the Th17/Treg balance are expounded. The maintenance of Th17/Treg balance could be considered as an therapeutic alternative for the treatment of RA and PMOP. This study also summarizes the advantages and disadvantages of conventional treatments and the quality of life and rehabilitation of patients with RA and PMOP. The findings presented her will provide a better understanding of the close relationship between bone immunity and bone remodelling in chronic bone diseases and new ideas for future research, prevention, and treatment of bone immune diseases. |
| first_indexed | 2024-03-08T09:42:03Z |
| format | Article |
| id | doaj.art-aeaed86306dc4ea6bac7bd1d7ba57fa3 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T09:42:03Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-aeaed86306dc4ea6bac7bd1d7ba57fa32024-01-30T04:22:02ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-01-011510.3389/fimmu.2024.13339931333993Research progress of targeted therapy regulating Th17/Treg balance in bone immune diseasesXiaxia Wang0Bai Sun1Yujie Wang2Peng Gao3Jiayi Song4Weirong Chang5Zhipan Xiao6Yongbin Xi7Zhonghong Li8Fangyu An9Chunlu Yan10School of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, ChinaSchool of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, ChinaSchool of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, ChinaSchool of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, ChinaSchool of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, ChinaSchool of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, ChinaSchool of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, ChinaOrthopaedics Department, The No.2 People’s Hospital of Lanzhou, Lanzhou, Gansu, ChinaPathological Research Centre, Gansu University of Chinese Medicine, Lanzhou, Gansu, ChinaTeaching Experiment Training Centre, Gansu University of Chinese Medicine, Lanzhou, Gansu, ChinaSchool of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, ChinaRheumatoid arthritis (RA) and postmenopausal osteoporosis (PMOP) are common bone-immune diseases. The imbalance between helper (Th17) and regulatory T cells (Tregs) produced during differentiation of CD4+ T cells plays a key regulatory role in bone remodelling disorders in RA and PMOP. However, the specific regulatory mechanism of this imbalance in bone remodelling in RA and PMOP has not been clarified. Identifying the regulatory mechanism underlying the Th17/Treg imbalance in RA and PMOP during bone remodelling represents a key factor in the research and development of new drugs for bone immune diseases. In this review, the potential roles of Th17, Treg, and Th17/Treg imbalance in regulating bone remodelling in RA and PMOP have been summarised, and the potential mechanisms by which probiotics, traditional Chinese medicine compounds, and monomers maintain bone remodelling by regulating the Th17/Treg balance are expounded. The maintenance of Th17/Treg balance could be considered as an therapeutic alternative for the treatment of RA and PMOP. This study also summarizes the advantages and disadvantages of conventional treatments and the quality of life and rehabilitation of patients with RA and PMOP. The findings presented her will provide a better understanding of the close relationship between bone immunity and bone remodelling in chronic bone diseases and new ideas for future research, prevention, and treatment of bone immune diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1333993/fullrheumatoid arthritispostmenopausal osteoporosistargeted therapyTh17/Treg equilibriumbone immunity |
| spellingShingle | Xiaxia Wang Bai Sun Yujie Wang Peng Gao Jiayi Song Weirong Chang Zhipan Xiao Yongbin Xi Zhonghong Li Fangyu An Chunlu Yan Research progress of targeted therapy regulating Th17/Treg balance in bone immune diseases Frontiers in Immunology rheumatoid arthritis postmenopausal osteoporosis targeted therapy Th17/Treg equilibrium bone immunity |
| title | Research progress of targeted therapy regulating Th17/Treg balance in bone immune diseases |
| title_full | Research progress of targeted therapy regulating Th17/Treg balance in bone immune diseases |
| title_fullStr | Research progress of targeted therapy regulating Th17/Treg balance in bone immune diseases |
| title_full_unstemmed | Research progress of targeted therapy regulating Th17/Treg balance in bone immune diseases |
| title_short | Research progress of targeted therapy regulating Th17/Treg balance in bone immune diseases |
| title_sort | research progress of targeted therapy regulating th17 treg balance in bone immune diseases |
| topic | rheumatoid arthritis postmenopausal osteoporosis targeted therapy Th17/Treg equilibrium bone immunity |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1333993/full |
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