Presenilin-1 interacts directly with the β-site amyloid protein precursor cleaving enzyme (BACE1)
A neuropathological hallmark of Alzheimer’s disease is the presence of amyloid plaques. The major constituent of these plaques, occurring largely in brain areas important for memory and cognition, is the 40–42 amyloid residues (Aβ). Aβ is derived from the amyloid protein precursor after cleavage by...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2003-08-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996103000354 |