Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma

Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma

Dermal myofibroblasts are responsible for fibrosis development in scleroderma. Here the authors show that a bioengineered recombinant human TRAIL ligand reverses established fibrosis in mouse models of scleroderma by targeting the death receptor 5 and inducing apoptosis of myofibroblasts.

Bibliographic Details
Main Authors: Jong-Sung Park, Yumin Oh, Yong Joo Park, Ogyi Park, Hoseong Yang, Stephanie Slania, Laura K. Hummers, Ami A. Shah, Hyoung-Tae An, Jiyeon Jang, Maureen R. Horton, Joseph Shin, Harry C. Dietz, Eric Song, Dong Hee Na, Eun Ji Park, Kwangmeyung Kim, Kang Choon Lee, Viktor V. Roschke, Justin Hanes, Martin G. Pomper, Seulki Lee
Format: Article
Language:English
Published: Nature Portfolio 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09101-4

Internet

https://doi.org/10.1038/s41467-019-09101-4

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