Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology

Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology

Abstract Background The rare p.H157Y variant of TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) was found to increase Alzheimer’s disease (AD) risk. This mutation is located at the cleavage site of TREM2 extracellular domain. Ectopic expression of TREM2-H157Y in HEK293 cells resulted in inc...

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Bibliographic Details
Main Authors: Wenhui Qiao, Yixing Chen, Jun Zhong, Benjamin J. Madden, Cristine M. Charlesworth, Yuka A. Martens, Chia-Chen Liu, Joshua Knight, Tadafumi C. Ikezu, Aishe Kurti, Yiyang Zhu, Axel Meneses, Cassandra L. Rosenberg, Lindsey A. Kuchenbecker, Lucy K. Vanmaele, Fuyao Li, Kai Chen, Francis Shue, Maxwell V. Dacquel, John Fryer, Akhilesh Pandey, Na Zhao, Guojun Bu
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Molecular Neurodegeneration
Subjects:
Trem2 H157Y mutation
Soluble TREM2
Microglia
Synaptic plasticity
Amyloid pathology
Aβ clearance
Online Access:https://doi.org/10.1186/s13024-023-00599-3

Internet

https://doi.org/10.1186/s13024-023-00599-3

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