Stable Sulforaphane Targets the Early Stages of Osteoclast Formation to Engender a Lasting Functional Blockade of Osteoclastogenesis

Sulforaphane, the native but unstable form of SFX-01, is an antioxidant that activates the NRF2 and inhibits the NF-KB pathways to achieve its actions. Resolving the mechanism(s) by which SFX-01 serves to control the various osteoclastogenic stages may expose pathways that could be explored for ther...

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Bibliographic Details
Main Authors: Polymnia Louka, Isabel R. Orriss, Andrew A. Pitsillides
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/13/2/165