Annexin A2 Stabilizes Oncogenic JAG1 Intracellular Domain by Inhibiting Proteasomal Degradation in Glioblastoma Cells

Annexin A2 Stabilizes Oncogenic JAG1 Intracellular Domain by Inhibiting Proteasomal Degradation in Glioblastoma Cells

Glioblastoma (GBM) is the most lethal brain cancer, causing inevitable deaths of patients owing to frequent relapses of cancer stem cells (CSCs). The significance of the NOTCH signaling pathway in CSCs has been well recognized; however, there is no NOTCH-selective treatment applicable to patients wi...

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Bibliographic Details
Main Authors: Seok Won Ham, Jung Yun Kim, Sunyoung Seo, Nayoung Hong, Min Ji Park, Yoonji Kim, Junseok Jang, Sehyeon Park, Silvee Jisoo Lee, Jun-Kyum Kim, Eun-Jung Kim, Sung-Ok Kim, Sung-Chan Kim, Jong-Whi Park, Hyunggee Kim
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
JAG1
JICD1
ANXA2
Glioblastoma
cancer stem cell
Online Access:https://www.mdpi.com/1422-0067/24/19/14776

Internet

https://www.mdpi.com/1422-0067/24/19/14776

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