Antibody Repertoire Analysis of Tumor-Infiltrating B Cells Reveals Distinct Signatures and Distributions Across Tissues

Antibody Repertoire Analysis of Tumor-Infiltrating B Cells Reveals Distinct Signatures and Distributions Across Tissues

The role of B cells in the tumor microenvironment (TME) has largely been under investigated, and data regarding the antibody repertoire encoded by B cells in the TME and the adjacent lymphoid organs are scarce. Here, we utilized B cell receptor high-throughput sequencing (BCR-Seq) to profile the ant...

Full description

Bibliographic Details
Main Authors: Ligal Aizik, Yael Dror, David Taussig, Adi Barzel, Yaron Carmi, Yariv Wine
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
antibody repertoire
BCR-Seq
tumor infiltrating lymphocytes
next generation sequencing
VDJ recombination
B cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.705381/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.705381/full

Similar Items