Extracellular Matrix From Hypertrophic Myocardium Provokes Impaired Twitch Dynamics in Healthy Cardiomyocytes

Extracellular Matrix From Hypertrophic Myocardium Provokes Impaired Twitch Dynamics in Healthy Cardiomyocytes

Summary: Hypertrophic cardiomyopathy (HCM) is often caused by single sarcomeric gene mutations that affect muscle contraction. Pharmacological correction of mutation effects prevents but does not reverse disease in mouse models. Suspecting that diseased extracellular matrix is to blame, we obtained...

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Bibliographic Details
Main Authors: Lorenzo R. Sewanan, MS, Jonas Schwan, PhD, Jonathan Kluger, BSE, Jinkyu Park, PhD, Daniel L. Jacoby, MD, Yibing Qyang, PhD, Stuart G. Campbell, PhD
Format: Article
Language:English
Published: Elsevier 2019-08-01
Series:JACC: Basic to Translational Science
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X19300774

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http://www.sciencedirect.com/science/article/pii/S2452302X19300774

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