Transcriptional regulation of the fidaxomicin gene cluster and cellular development in Actinoplanes deccanensis YP-1 by the pleiotropic regulator MtrA

Transcriptional regulation of the fidaxomicin gene cluster and cellular development in Actinoplanes deccanensis YP-1 by the pleiotropic regulator MtrA

ABSTRACT Fidaxomicin is an 18-membered glycosidic macrolide polyketide that was clinically used in the treatment of Clostridium difficile infection in 2011. Although the biosynthetic mechanism and pathway-specific regulator of fidaxomicin were well elaborated, little is known about the pleiotropic r...

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Bibliographic Details
Main Authors: Huang Xie, Jing-Yi Ruan, Qing-Ting Bu, Yue-Ping Li, Yi-Ting Su, Qing-Wei Zhao, Yi-Ling Du, Yong-Quan Li
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:Microbiology Spectrum
Subjects:
fidaxomicin
protein-DNA interaction
two-component system
MtrA
transcriptome
morphological development
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02702-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.02702-23

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