LONG-TERM RHEOLOGICAL BENEFITS OF GBT021601 IMPROVE PATHOLOGICAL ANGIOGENESIS IN THE SICKLE MOUSE BONE MARROW AND PREVENTS DEVELOPMENT OF HYPERALGESIA.
Background: In sickle cell disease (SCD), the abnormal sickle hemoglobin (HbS) on deoxygenation, polymerizes causing repeated vaso-occlusive episodes and hypoxic injury leading to significant morbidity and mortality. Acute pain is the single most cause of hospitalization, but by adulthood, 55% devel...
| Hauptverfasser: | , , , , |
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| Format: | Artikel |
| Sprache: | English |
| Veröffentlicht: |
Elsevier
2024-10-01
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| Schriftenreihe: | Hematology, Transfusion and Cell Therapy |
| Online Zugang: | http://www.sciencedirect.com/science/article/pii/S2531137924006199 |