miR-125b-5p in adipose derived stem cells exosome alleviates pulmonary microvascular endothelial cells ferroptosis via Keap1/Nrf2/GPX4 in sepsis lung injury

miR-125b-5p in adipose derived stem cells exosome alleviates pulmonary microvascular endothelial cells ferroptosis via Keap1/Nrf2/GPX4 in sepsis lung injury

Background: Sepsis is a fatal disease with a high rate of morbidity and mortality, during which acute lung injury is the earliest and most serious complication. Injury of pulmonary microvascular endothelial cells (PMVECs) induced by excessive inflammation plays an important role in sepsis acute lung...

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Bibliographic Details
Main Authors: Kuo Shen, Xujie Wang, Yunwei Wang, Yanhui Jia, Yue Zhang, Kejia Wang, Liang Luo, Weixia Cai, Jin Li, Shaohui Li, Yuting Du, Lixia Zhang, Hao Zhang, Yuxi Chen, Chaolei Xu, Jinxin Zhang, Ruizhi Wang, Xuekang Yang, Yunchuan Wang, Dahai Hu
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Redox Biology
Subjects:
ADSCs exosome
Sepsis
Acute lung injury
Ferroptosis
GPX4
Nrf2
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723000563

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http://www.sciencedirect.com/science/article/pii/S2213231723000563

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