Structural mechanism for guanylate-binding proteins (GBPs) targeting by the Shigella E3 ligase IpaH9.8.
The guanylate-binding proteins (GBPs) belong to the dynamin superfamily of GTPases and function in cell-autonomous defense against intracellular pathogens. IpaH9.8, an E3 ligase from the pathogenic bacterium Shigella flexneri, ubiquitinates a subset of GBPs and leads to their proteasomal degradation...
| Autores principales: | , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | English |
| Publicado: |
Public Library of Science (PLoS)
2019-06-01
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| Colección: | PLoS Pathogens |
| Acceso en línea: | https://doi.org/10.1371/journal.ppat.1007876 |