Nucleotide-Specific Contrast for DNA Sequencing by Electron Spectroscopy.

DNA sequencing by imaging in an electron microscope is an approach that holds promise to deliver long reads with low error rates and without the need for amplification. Earlier work using transmission electron microscopes, which use high electron energies on the order of 100 keV, has shown that low...

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Bibliographic Details
Main Authors: Marian Mankos, Henrik H J Persson, Alpha T N'Diaye, Khashayar Shadman, Andreas K Schmid, Ronald W Davis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4858156?pdf=render