Transcriptomic analysis of the innate immune response to in vitro transfection of plasmid DNA

Transcriptomic analysis of the innate immune response to in vitro transfection of plasmid DNA

The innate immune response to cytosolic DNA is intended to protect the host from viral infections, but it can also inhibit the delivery and expression of therapeutic transgenes in gene and cell therapies. The goal of this work was to use mRNA sequencing to identify genes that may influence transfect...

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Bibliographic Details
Main Authors: Eric Warga, Jared Anderson, Matthew Tucker, Emily Harris, Jacob Elmer
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and applications
plasmid
innate immune response
cytokines
cytokine-stimulated genes
IFI16
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253122003171

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http://www.sciencedirect.com/science/article/pii/S2162253122003171

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