Prion-derived tetrapeptide stabilizes thermolabile insulin via conformational trapping

Prion-derived tetrapeptide stabilizes thermolabile insulin via conformational trapping

Summary: Unfolding followed by fibrillation of insulin even in the presence of various excipients grappled with restricted clinical application. Thus, there is an unmet need for better thermostable, nontoxic molecules to preserve bioactive insulin under varying physiochemical perturbations. In searc...

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Bibliographic Details
Main Authors: Meghomukta Mukherjee, Debajyoti Das, Jit Sarkar, Nilanjan Banerjee, Jagannath Jana, Jyotsna Bhat, Jithender Reddy G, Jagadeesh Bharatam, Samit Chattopadhyay, Subhrangsu Chatterjee, Partha Chakrabarti
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:iScience
Subjects:
Medical biochemistry
Molecular physiology
Biomolecular engineering
Structural biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221005411

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http://www.sciencedirect.com/science/article/pii/S2589004221005411

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