Tension-driven multi-scale self-organisation in human iPSC-derived muscle fibers

Tension-driven multi-scale self-organisation in human iPSC-derived muscle fibers

Human muscle is a hierarchically organised tissue with its contractile cells called myofibers packed into large myofiber bundles. Each myofiber contains periodic myofibrils built by hundreds of contractile sarcomeres that generate large mechanical forces. To better understand the mechanisms that coo...

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Bibliographic Details
Main Authors: Qiyan Mao, Achyuth Acharya, Alejandra Rodríguez-delaRosa, Fabio Marchiano, Benoit Dehapiot, Ziad Al Tanoury, Jyoti Rao, Margarete Díaz-Cuadros, Arian Mansur, Erica Wagner, Claire Chardes, Vandana Gupta, Pierre-François Lenne, Bianca H Habermann, Olivier Theodoly, Olivier Pourquié, Frank Schnorrer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-08-01
Series:eLife
Subjects:
muscle
sarcomere
self-organisation
mechanical tension
human induced pluripotent stem cells
myofibril
Online Access:https://elifesciences.org/articles/76649

Internet

https://elifesciences.org/articles/76649

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