Distinct and overlapping roles of STAG1 and STAG2 in cohesin localization and gene expression in embryonic stem cells

Distinct and overlapping roles of STAG1 and STAG2 in cohesin localization and gene expression in embryonic stem cells

Abstract Background The three-dimensional organization of the genome in the nucleus plays an integral role in many biological processes, including gene expression. The genome is folded into DNA loops that bring together distal regulatory elements and genes. Cohesin, a ring-shaped protein complex, is...

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Bibliographic Details
Main Authors: Nicole L. Arruda, Zachary M. Carico, Megan Justice, Ying Frances Liu, Junjie Zhou, Holden C. Stefan, Jill M. Dowen
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Epigenetics & Chromatin
Subjects:
Cohesin
STAG
Transcription
Gene expression
Enhancers
Promoters
Online Access:http://link.springer.com/article/10.1186/s13072-020-00353-9

Internet

http://link.springer.com/article/10.1186/s13072-020-00353-9

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