Relation between DNA ionization potentials, single base substitutions and pathogenic variants

Relation between DNA ionization potentials, single base substitutions and pathogenic variants

Abstract Background It is nowadays clear that single base substitutions that occur in the human genome, of which some lead to pathogenic conditions, are non-random and influenced by their flanking nucleobase sequences. However, despite recent progress, the understanding of these "non-local"...

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Bibliographic Details
Main Authors: Fabrizio Pucci, Marianne Rooman
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Genomics
Subjects:
Single base substitutions
Pathogenic mutations
Charge transport
DNA base stacking
Vertical ionization potential
Online Access:http://link.springer.com/article/10.1186/s12864-019-5867-y

Internet

http://link.springer.com/article/10.1186/s12864-019-5867-y

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