MDMA, methamphetamine, and CYP2D6 pharmacogenetics: what is clinically relevant?

MDMA, methamphetamine, and CYP2D6 pharmacogenetics: what is clinically relevant?

In vitro human studies show that the metabolism of most amphetamine-like psychostimulants is regulated by the polymorphic cytochrome P450 isozyme CYP2D6. Two compounds, methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA), were selected as archetypes to discuss the translation and clinical s...

Full description

Bibliographic Details
Main Authors: Rafael eDe La Torre, Samanta eYubero-Lahoz, Ricardo ePardo-Lozano, Magi eFarre
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-11-01
Series:Frontiers in Genetics
Subjects:
Methamphetamine
Pharmacogenetics
CYP2D6
MDMA
ecstasy
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00235/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00235/full

Similar Items