Targeting ectodysplasin promotor by CRISPR/dCas9-effector effectively induces the reprogramming of human bone marrow-derived mesenchymal stem cells into sweat gland-like cells

Targeting ectodysplasin promotor by CRISPR/dCas9-effector effectively induces the reprogramming of human bone marrow-derived mesenchymal stem cells into sweat gland-like cells

Abstract Background Patients with a deep burn injury are characterized by losing the function of perspiration and being unable to regenerate the sweat glands. Because of their easy accession, multipotency, and lower immunogenicity, bone marrow-derived mesenchymal stem cells (BM-MSCs) represent as an...

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Bibliographic Details
Main Authors: Sujing Sun, Jun Xiao, Jiahui Huo, Zhijun Geng, Kui Ma, Xiaoyan Sun, Xiaobing Fu
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Stem Cell Research & Therapy
Subjects:
Ectodysplasin (EDA)
dCas9-effector
Gene editing
Regeneration
Sweat gland cells
Online Access:http://link.springer.com/article/10.1186/s13287-017-0758-0

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http://link.springer.com/article/10.1186/s13287-017-0758-0

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