A Comparison of DNA Mutation and Copy Number Profiles of Primary Breast Cancers and Paired Brain Metastases for Identifying Clinically Relevant Genetic Alterations in Brain Metastases

A Comparison of DNA Mutation and Copy Number Profiles of Primary Breast Cancers and Paired Brain Metastases for Identifying Clinically Relevant Genetic Alterations in Brain Metastases

Improving the systemic treatment of brain metastases (BM) in primary breast cancer (PBC) is impaired by the lack of genomic characterization of BM. To estimate the concordance of DNA copy-number-alterations (CNAs), mutations, and actionable genetic alterations (AGAs) between paired samples, we perfo...

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Bibliographic Details
Main Authors: Marguerite Tyran, Nadine Carbuccia, Séverine Garnier, Arnaud Guille, José Adelaïde, Pascal Finetti, Julien Toulzian, Patrice Viens, Agnès Tallet, Anthony Goncalves, Philippe Metellus, Daniel Birnbaum, Max Chaffanet, François Bertucci
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cancers
Subjects:
brain metastasis
breast cancer
copy number profiling
mutation
targeted therapy
Online Access:https://www.mdpi.com/2072-6694/11/5/665

Internet

https://www.mdpi.com/2072-6694/11/5/665

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