Structural insights into the agonists binding and receptor selectivity of human histamine H4 receptor

Structural insights into the agonists binding and receptor selectivity of human histamine H4 receptor

Abstract Histamine is a biogenic amine that participates in allergic and inflammatory processes by stimulating histamine receptors. The histamine H4 receptor (H4R) is a potential therapeutic target for chronic inflammatory diseases such as asthma and atopic dermatitis. Here, we show the cryo-electro...

Full description

Bibliographic Details
Main Authors: Dohyun Im, Jun-ichi Kishikawa, Yuki Shiimura, Hiromi Hisano, Akane Ito, Yoko Fujita-Fujiharu, Yukihiko Sugita, Takeshi Noda, Takayuki Kato, Hidetsugu Asada, So Iwata
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42260-z

Internet

https://doi.org/10.1038/s41467-023-42260-z

Similar Items