Bis(Disulfide)-Bridged Somatostatin-14 Analogs and Their [<sup>111</sup>In]In-Radioligands: Synthesis and Preclinical Profile

Bis(Disulfide)-Bridged Somatostatin-14 Analogs and Their [<sup>111</sup>In]In-Radioligands: Synthesis and Preclinical Profile

The overexpression of one or more somatostatin receptors (SST<sub>1–5</sub>R) in human tumors has provided an opportunity for diagnosis and therapy with somatostatin-like radionuclide carriers. The application of “pansomatostatin” analogs is expected to broaden the clinical indications a...

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Bibliographic Details
Main Authors: Aikaterini Tatsi, Theodosia Maina, Beatrice Waser, Eric P. Krenning, Marion de Jong, Jean Claude Reubi, Paul Cordopatis, Berthold A. Nock
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
DOTA-conjugated somatostatin
[<sup>111</sup>In]In-radioligand
bicyclic somatostatin
metabolic stability
tumor targeting
theranostics
Online Access:https://www.mdpi.com/1422-0067/25/3/1921

Internet

https://www.mdpi.com/1422-0067/25/3/1921

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