Genome-wide CRISPR/Cas9 screening identifies a targetable MEST-PURA interaction in cancer metastasisResearch in context

Genome-wide CRISPR/Cas9 screening identifies a targetable MEST-PURA interaction in cancer metastasisResearch in context

Summary: Background: Metastasis is one of the most lethal hallmarks of esophageal squamous cell carcinoma (ESCC), yet the mechanisms remain unclear due to a lack of reliable experimental models and systematic identification of key drivers. There is urgent need to develop useful therapies for this l...

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Bibliographic Details
Main Authors: Wen Wen Xu, Long Liao, Wei Dai, Can-Can Zheng, Xiang-Peng Tan, Yan He, Qi-Hua Zhang, Zhi-Hao Huang, Wen-You Chen, Yan-Ru Qin, Kui-Sheng Chen, Ming-Liang He, Simon Law, Maria Li Lung, Qing-Yu He, Bin Li
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:EBioMedicine
Subjects:
Cancer metastasis
CRISPR/Cas9 screening
Protein interactome
Noncoding RNA
Esophageal cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396423001524

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http://www.sciencedirect.com/science/article/pii/S2352396423001524

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