Single-cell sequencing reveals the heterogeneity of B cells and tertiary lymphoid structures in muscle-invasive bladder cancer

Single-cell sequencing reveals the heterogeneity of B cells and tertiary lymphoid structures in muscle-invasive bladder cancer

Abstract Background Muscle-invasive bladder cancer (MIBC) is a highly aggressive disease with a poor prognosis. B cells are crucial factors in tumor suppression, and tertiary lymphoid structures (TLSs) facilitate immune cell recruitment to the tumor microenvironment (TME). However, the function and...

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Bibliographic Details
Main Authors: Hao Yuan, Xingning Mao, Yunkun Yan, Rong Huang, Qingyun Zhang, Yanyu Zeng, Mengying Bao, Yan Dai, Bo Fang, Junhao Mi, Yuli Xie, Xiang Wang, Haiying Zhang, Zengnan Mo, Rirong Yang
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Translational Medicine
Subjects:
B cells
Tertiary lymphoid structures
Muscle-invasive bladder cancer
Single-cell sequencing
CXCL13
Online Access:https://doi.org/10.1186/s12967-024-04860-1

Internet

https://doi.org/10.1186/s12967-024-04860-1

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