Inactivation of TRPM2 channels by extracellular divalent copper.

Cu2+ is an essential metal ion that plays a critical role in the regulation of a number of ion channels and receptors in addition to acting as a cofactor in a variety of enzymes. Here, we showed that human melastatin transient receptor potential 2 (hTRPM2) channel is sensitive to inhibition by extra...

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Bibliographic Details
Main Authors: Wenyue Yu, Lin-Hua Jiang, Yang Zheng, Xupang Hu, Jianhong Luo, Wei Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4227687?pdf=render