Thromboxane-induced contractile response of mesenteric arterioles is diminished in the older rats and the older hypertensive rats

Thromboxane-induced contractile response of mesenteric arterioles is diminished in the older rats and the older hypertensive rats

Nearly all physiological processes are controlled at some level by G-protein-coupled receptor (GPCR) signaling activity. The thromboxane A2 (TXA2) receptor (TP) is a member of the GPCR family. The ultimate effect of TP receptor activation depends on the availability of specific G proteins, which in...

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Bibliographic Details
Main Authors: Min Zhang, Chunshu Li, Chunxia He, Yiqin Cui, Yuan Li, Ying Ma, Jun Cheng, Jing Wen, Pengyun Li, Yan Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
aging-related vascular remodeling
mesenteric artery
U-46619
vasoconstriction
TXA2-TP prostaglandin signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1019511/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.1019511/full

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